Endocrine Abstracts

Skeletal muscle and adipose tissue has been identified as an endocrine organ and their metabolism exerts an impact on whole-body metabolism. Endocrine functions attributed to adipokines and myokines are involved in body weight regulation and insulin sensitivity. Obesity is associated with dys-regulation of adipose tissue and skeletal muscle metabolism and is accompanied with insulin resistance. Our study investigates the effect of insulin regulated aminopeptidase (IRAP) inhibi...

Introduction: Lactose intolerance itself is linked with lower peak bone mass (PBM) and with decreased bone mineral density (BMD) which may decrease further with lactose intolerance associated comorbidities. The aim of our study was to examine how bone metabolic parameters are affected (change of bone metabolism markers, BMD and frequency of fractures) in lactose intolerance which was accompanied by previously diagnosed hyperlipidemia or by hypothyroidism.<p class="abstext"...

Introduction: Polycystic ovary syndrome (PCOS), lactase deficiency, nephrolithisasis and thyroid diseases are considered endemic. The aim of our study was to evaluate which of the above-mentioned diseases affect the most the bone metabolic parameters, bone mineral density (BMD) and the prevalence of bone fractures in fertile aged women.Materials and methods: A total of 92 fertile aged women (32.6±5.2 years) were divided into four groups (23 in each)...

Fibroblast growth factor-21 (FGF-21) is a novel regulator of metabolic homeostasis that improved diabetes compensation and dyslipidemia in diabetic mice and monkeys. However, little is known about its regulation in humans. Cushing’s syndrome (CS) is characterized by endogenous hypercortisolism and is often associated with numerous metabolic abnormalities. The objective of this study was to test the hypothesis that CS is associated with altered levels of FGF 21 that may in...

Our aim was to investigate whether pollen-allergy can affect fractures in postmenopausal women. A total of 125 postmenopausal pollen-allergic women (mean age 61.26 yr) were split into four groups: treated neither with H1 histamine receptor (H1R) antagonist nor with inhaled corticosteroid (n=43), treated only with H1R antagonist (n=53), treated both with H1R antagonist and inhaled corticosteroid (n=17), treated only with inhaled corticosteroid (n=12)...

Histamine receptor antagonists seem to have effect on bone metabolism according to previous studies. We investigated the bone turnover in allergic children who were treated with H1 hisztamin receptor (H1R) antagonists.The biochemical bone turnover markers [β-CrossLapps (β-CTx), osteocalcin (OCN), β-CTx/OCN ratio], parathyroid hormone (PTH) and the 25-OH-vitamin D3 were determined in 37 H1R antagonist treated multiplex allergic c...

ContextPrenatal dexamethasone (Dex) therapy is used in female foetuses with congenital adrenal hyperplasia (CAH) to suppress adrenal androgen excess and prevent virilisation of the external genitalia. The prenatal dexamethasone dose of 20 µg/kg per day has been used for decades in prenatal CAH and is associated with risks for the treated mother and potentially for the unborn child. Despite the high medical need, no prospective, clinical studies had ...

Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting 10-15% of women worldwide, characterized by high androgen levels, anovulation and/or polycystic ovarian morphology. Chronic low-grade inflammation is associated with the disorder as well as many of its comorbidities, such as obesity and type-2 diabetes. To determine the role of the immune system in the pathophysiology of PCOS, we characterized the immune profile of the dihydrotestosterone (DHT)-induced PCOS-li...

Introduction: Polycystic ovary syndrome (PCOS) is the leading cause of female infertility and is associated with high degree of comorbidities including type 2 diabetes and endometrial cancer. Hyperandrogenemia is a hallmark of PCOS and contributes to endometrial-related dysfunctions, including implantation failure and miscarriage. Whether cellular heterogeneity contributes to the functioning of the endometrium is not previously studied. Therefore, the aim is to reveal cell-typ...

White adipose tissue (WAT) is a dynamic and heterogeneous organ composed of different cell types involved in a wide array of biological processes. We know that women with polycystic ovary syndrome (PCOS) suffer from insulin resistance and type 2 diabetes which is associated with pathological white adipose tissue (WAT) function and expansion characterized by hypertrophic adipocytes, altered production and release of lipids and adipokines, and chronic low-grade tissue inflammati...